Lung disease

Upper Lobe Disease

General

• Mnemonic = SSET CAP

  • Silicosis

  • Sarcoidosis

  • Esoinophilic - Langerhans

  • TB & Fungal

  • Cystic fibrosis

  • Ankylosing Spondylitis

  • PCP pneumonia

Langerhans

• Pulmonary Langerhans seen in 20-40 year olds

• Associated with smoking

• CXR

  • Diffuse bilateral reticulonodular pattern

  • Small peribronchovascular nodules to large cysts

• CT

  • Nodules seen earlier in disease

  • Cysts seen later in disease

    • Bizzare shapes with septa,

    • Thin walled

  • Fibrosis and honeycombing later in disease

Lower lung Disease

General

• Mnemonic = BAD RASH

  • Bronchiectasis

  • Aspiration

  • DIP

  • RA associated lung disease

  • Asbestosis

  • Scleroderma

  • Hamman-Rich Syndrome - Acute interstitial pneumonia

OTHER DISEASE

Differentiation Syndrome (All Trans Retinoic Acid (ATRA) Syndrome )

• Patients with Acute promyelocytic leukemia get chemo drug —> causes tumor cells to mature —> capillaries leak —> pulmonary edema

  • Also seen with AML

• Classically, but not exclusively with ATRA

• Basically looks like non-cardiogenic pulmonary edema

• Tx - steroids

LAM

• Abnormal proliferation of smooth muscle

• Triad of

  • Thin walled pulmonary cysts

  • Lymph issues

    • Chylothorax

  • AMLs

• Associated with tuberous sclerosis in males

• Get pneumothorax