General Nuclear Medicine

Mechanisms of Radiotracer Localization

  • This is basically the MOA of how the tracer gets picked up

  • Chemisorption

    • Tc-99 MDP for Bone Scan

  • Phagocytosis

    • Tc-99m Sulfur colloid - for liver spleen scan

  • Receptor binding

    • Dotatate PET for neuroendocrine tumors

  • Active Transport

    • I123 or I-131

  • Passive Diffusion

    • Xenon-133 (for V/q?)

  • Capillary Blockade

    • Tc-99m MAA

  • Cell Sequestration

    • Heat damaged RBC for spleen imaging

Ref